Journal
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Sciences du comportement
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Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder
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Sciences du comportement
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Journal JoVE Sciences du comportement
Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder

Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder

DOI:
10.3791/58306-v

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05:49 min

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October 13, 2018

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, ,
1Department of Psychology,University of California, Los Angeles, 2Staglin Center for Brain and Behavioral Health,University of California, Los Angeles, 3Department of Psychiatry and Biobehavioral Sciences,University of California, Los Angeles

Chapitres

  • 00:04Titre
  • 00:33Experimental Setup
  • 01:48SEFL Procedure
  • 04:41Results: Trauma Animals Show High Levels of Freezing and Lower Shock Reactivity Compared to Controls
  • 05:26Conclusion

Summary

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Traduction automatique

Here we describe the detailed methodology required to conduct stress-enhanced fear learning (SEFL) experiments, a preclinical model of post-traumatic stress disorder, in both rats and mice. The model utilizes aspects of Pavlovian fear conditioning and freezing as an index of enhanced fear in rodents.

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Stress-enhanced Fear LearningPTSD ModelRodent ModelFear ConditioningContext AContext BFoot ShockShock GeneratorScramblerGrid FloorPlexiglass InsertTrauma Conditioning

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