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Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder
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Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder
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October 13, 2018
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Here we describe the detailed methodology required to conduct stress-enhanced fear learning (SEFL) experiments, a preclinical model of post-traumatic stress disorder, in both rats and mice. The model utilizes aspects of Pavlovian fear conditioning and freezing as an index of enhanced fear in rodents.
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Rajbhandari, A. K., Gonzalez, S. T., Fanselow, M. S. Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder. J. Vis. Exp. (140), e58306, doi:10.3791/58306 (2018).
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