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JoVE Journal Neuroscience
Monitoring Cell-to-cell Transmission of Prion-like Protein Aggregates in Drosophila Melanogaster
 

Monitoring Cell-to-cell Transmission of Prion-like Protein Aggregates in Drosophila Melanogaster

Article DOI: 10.3791/56906-v • 10:26 min • March 12th, 2018
March 12th, 2018 •
1, 1
1Department of Biological Sciences, University of the Sciences

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Accumulating evidence supports the idea that pathogenic protein aggregates associated with neurodegenerative diseases spread between cells with prion-like properties. Here, we describe a method that enables visualization of cell-to-cell spreading of prion-like aggregates in the model organism, Drosophila melanogaster.

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Prion-like Protein Aggregates Monitoring Drosophila Melanogaster Transgenic Flies Aggregation Prone Protein Cell-to-cell Transmission Neurodegeneration Protein Aggregate Spreading Intact Central Nervous System Imaging Huntington's Disease Prion-like Neurodegenerative Diseases Culturing Conditions Gal4 Or QF Drivers Huntingtin Transgenes Brain Dissection
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