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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
JoVE Journal
Neurociência
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JoVE Journal Neurociência
A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

9,490 Views

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07:02 min

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February 11, 2019

DOI:

10.3791/56569-v

DOI:
10.3791/56569-v

•

07:02 min
February 11, 2019

•

2 Views
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1Centre for Human Drug Research (CHDR), Leiden

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PharmacodynamicCentral Nervous SystemCholinergic DrugsEarly Phase Drug DevelopmentNeuropsychologicalNeurophysiologicalTest BatteryRepeated MeasurementsConcentration Effects RelationshipsDose EscalationComputerized TestEye ElectrodesEEGSubject Performance

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Hart, E. P., Alvarez-Jimenez, R., Davidse, E., Doll, R. J., Cohen, A. F., Van Gerven, J. M., Groeneveld, G. J. A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development. J. Vis. Exp. (144), e56569, doi:10.3791/56569 (2019).

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