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Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model
JoVE Journal
Medicina
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JoVE Journal Medicina
Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model

Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model

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09:22 min

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April 02, 2017

DOI:

10.3791/54729-v

DOI:
10.3791/54729-v

•

09:22 min
April 02, 2017

•

2 Views
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1Collaboration for Organ Perfusion, Protection, Engineering and Regeneration (COPPER) Lab, Division of Transplant, Department of Surgery, Comprehensive Transplant Center,The Ohio State University Wexner Medical Center

Summary

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A unique rat liver hilar clamp model was developed for studying the impact of pharmacologic molecules in ameliorating ischemia-reperfusion injury. This model includes direct cannulation of the portal supply to the ischemic liver segment via a branch of the portal vein, allowing for direct hepatic delivery.

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Cite this Article

Beal, E. W., Dumond, C., Kim, J., Mumtaz, K., Hayes Jr., D., Washburn, K., Whitson, B. A., Black, S. M. Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model. J. Vis. Exp. (122), e54729, doi:10.3791/54729 (2017).

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