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Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model
JoVE 杂志
医学
This content is Free Access.
JoVE 杂志 医学
Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model

Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model

DOI:
10.3791/54729-v

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09:22 min

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April 02, 2017

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, , , , , , ,
1Collaboration for Organ Perfusion, Protection, Engineering and Regeneration (COPPER) Lab, Division of Transplant, Department of Surgery, Comprehensive Transplant Center,The Ohio State University Wexner Medical Center

Chapters

  • 00:05Title
  • 00:57Rat Hilar Clamp Placement
  • 05:44Monitoring, Reperfusion and Continued Sampling
  • 07:19Results: Direct Segmental Intrahepatic Delivery of PEG-SOD Using the Rat Hilar Clamp Model
  • 08:43Conclusion

Summary

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A unique rat liver hilar clamp model was developed for studying the impact of pharmacologic molecules in ameliorating ischemia-reperfusion injury. This model includes direct cannulation of the portal supply to the ischemic liver segment via a branch of the portal vein, allowing for direct hepatic delivery.

Tags

Rat Liver Hilar Clamp ModelIschemia Reperfusion InjuryOrgan TransplantationPortal VeinDirect Segmental Intrahepatic DeliveryOrgan PerfusatesLiver TransplantationPharmacologic MoleculesSurgical Technique

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