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造型中风小鼠：在远端大脑中动脉永久性混凝

JoVE Journal
Medicina

This content is Free Access.

JoVE Journal Medicina

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

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造型中风小鼠：在远端大脑中动脉永久性混凝

DOI:

10.3791/51729-v

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08:14 min

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July 31, 2014

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Gemma Llovera*^1,2, Stefan Roth*^1,2, Nikolaus Plesnila², Roland Veltkamp⁴, Arthur Liesz²

¹Institute for Stroke and Dementia Research,University Hospital Munich, ²Munich Cluster for Systems Neurology (SyNergy), ³Department of Neurology,University Heidelberg, ⁴Imperial College,Charing Cross Hospital

Capítulos

00:05Título
01:38Preparations
02:32The Distal MCAO Model
04:52The Cylinder Test
05:45Measuring the Infarction
06:31Mortality, Behavioral Change, and Infarct Characterization
07:30Conclusion

Summary

Tadução automática

大脑中动脉闭塞（MCAO）的各种小鼠模型被广泛应用于实验性脑研究。这里，我们表明经颅永久远侧MCAO模型，产生对应于由多数人的缺血性中风的损害施加一个大小一致的皮层梗死。

Tags

Keywords: Stroke Mouse Model Middle Cerebral Artery Coagulation Infarct Permanent Occlusion Cortex Reproducibility Low Mortality Pathophysiology Inflammation Angiogenesis Plasticity Regeneration Therapeutic Strategies

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