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The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
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Medicina
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JoVE Journal Medicina
The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

47,203 Views

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07:09 min

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July 16, 2014

DOI:

10.3791/51608-v

DOI:
10.3791/51608-v

•

07:09 min
July 16, 2014

•

64 Views
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1Institut des Neurosciences Cellulaires et Intégratives UPR3212,Centre National de la Recherche Scientifique, 2Université de Strasbourg, 3Hôpitaux Universitaires de Strasbourg

Summary

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Neuropathic pain is a consequence of a lesion or disease affecting the somatosensory system. The “cuff model” of neuropathic pain in mice consists of the implantation of a polyethylene cuff around the main branch of the sciatic nerve. Mechanical allodynia is tested using von Frey filaments.

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Cite this Article

Yalcin, I., Megat, S., Barthas, F., Waltisperger, E., Kremer, M., Salvat, E., Barrot, M. The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice. J. Vis. Exp. (89), e51608, doi:10.3791/51608 (2014).

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