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JoVE Journal Medicine
Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts
 

Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts

Article DOI: 10.3791/51123-v • 08:15 min • February 11th, 2014
February 11th, 2014 •
1, 1, 1, 1, 1, 1, 1
1Department of Urologic Sciences, University of British Columbia

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Resumo
Automatic Translation

The established technique to inoculate primary invasive orthotopic bladder cancer xenografts requires laparotomy and mobilization of the bladder. This procedure inflicts significant morbidity on the mice, is technically challenging and time-consuming. We therefore developed a high-precision, percutaneous approach utilizing ultrasound guidance.

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Orthotopic Bladder Xenografts Minimally Invasive Establishment Murine Model Intravesical Instillation Intramural Injection Molecular Cellular Manipulations Therapeutic Agents Tumorigenic Ultrasound Guidance Percutaneous Inoculation Athymic Nude Mice Bioluminescence Imaging Tumor Growth Monitoring
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