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Neuroscience

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JoVE Journal Neuroscience
Establishing Intracranial Brain Tumor Xenografts With Subsequent Analysis of Tumor Growth and Response to Therapy using Bioluminescence Imaging
 

Establishing Intracranial Brain Tumor Xenografts With Subsequent Analysis of Tumor Growth and Response to Therapy using Bioluminescence Imaging

Article DOI: 10.3791/1986-v • 11:10 min • July 13th, 2010
July 13th, 2010 •
1, 1
1Department of Neurological Surgery, University of California, San Francisco - UCSF

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Luciferase-modified human brain tumor xenografts can be established intracranially in athymic mice, with subsequent monitoring of tumor growth and response to therapy using bioluminescence imaging. In combination with survival analysis, bioluminescence monitoring is an essential research tool for pre-clinical testing of therapies being considered for treating brain tumors.

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Intracranial Brain Tumor Xenografts Tumor Growth Therapy Response Bioluminescence Imaging Transplantation Models Neuro-oncology Research Human Tumor Xenograft Subcutaneous Injection Immunocompromised Mice Orthotopic Xenograft Establishment Neuroanatomical Structures Intracranial Xenograft Establishment Tumor Burden Non-invasive Imaging Bioluminescence Monitoring Orthotopic Brain Tumor Establishment Experimental Therapies
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