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Establishing Intracranial Brain Tumor Xenografts With Subsequent Analysis of Tumor Growth and Response to Therapy using Bioluminescence Imaging
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July 13, 2010
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Luciferase-modified human brain tumor xenografts can be established intracranially in athymic mice, with subsequent monitoring of tumor growth and response to therapy using bioluminescence imaging. In combination with survival analysis, bioluminescence monitoring is an essential research tool for pre-clinical testing of therapies being considered for treating brain tumors.
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Intracranial Brain Tumor XenograftsTumor GrowthTherapy ResponseBioluminescence ImagingTransplantation ModelsNeuro-oncology ResearchHuman Tumor XenograftSubcutaneous InjectionImmunocompromised MiceOrthotopic Xenograft EstablishmentNeuroanatomical StructuresIntracranial Xenograft EstablishmentTumor BurdenNon-invasive ImagingBioluminescence MonitoringOrthotopic Brain Tumor EstablishmentExperimental Therapies
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Ozawa, T., James, C. D. Establishing Intracranial Brain Tumor Xenografts With Subsequent Analysis of Tumor Growth and Response to Therapy using Bioluminescence Imaging. J. Vis. Exp. (41), e1986, doi:10.3791/1986 (2010).
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