This content is Free Access.
Mouse Models of Periventricular Leukomalacia
29,292 Views
•
06:24 min
•
May 18, 2010
DOI:
Summary
Automatically generated
We established mouse models of periventricular leukomalacia (PVL), the predominant brain injury in premature infants characterized by periventricular white matter lesions. Hypoxia/ischemia with/without systemic infection are the primary causes of PVL. Unilateral carotid ligation and hypoxia exposure with/without lipopolysaccharide injection creates PVL-like lesions in P6 mice.
Explore More Videos
Mouse ModelsPeriventricular LeukomalaciaPVLBrain InjuryPremature InfantsCerebral PalsyWhite Matter DamageOligodendroglial InjuryHypoxia/ischemiaSystemic Infection/inflammationP6 MiceNeonatal Brain InjuryCarotid LigationEndotoxin Lipopolysaccharide (LPS)Myelin Basic Protein (MBP)O1Electron Microscopic ExaminationHippocampusThalamusDisease PathogenesisTransgenic Mouse StrainsDrug TrialsTherapeutic AgentsStem Cell TransplantationImmunodeficiency Mouse Strains
Read Article
Cite this Article
Shen, Y., Plane, J. M., Deng, W. Mouse Models of Periventricular Leukomalacia. J. Vis. Exp. (39), e1951, doi:10.3791/1951 (2010).
Copy