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Mouse Models of Periventricular Leukomalacia
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May 18, 2010
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We established mouse models of periventricular leukomalacia (PVL), the predominant brain injury in premature infants characterized by periventricular white matter lesions. Hypoxia/ischemia with/without systemic infection are the primary causes of PVL. Unilateral carotid ligation and hypoxia exposure with/without lipopolysaccharide injection creates PVL-like lesions in P6 mice.
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Mouse ModelsPeriventricular LeukomalaciaPVLBrain InjuryPremature InfantsCerebral PalsyWhite Matter DamageOligodendroglial InjuryHypoxia/ischemiaSystemic Infection/inflammationP6 MiceNeonatal Brain InjuryCarotid LigationEndotoxin Lipopolysaccharide (LPS)Myelin Basic Protein (MBP)O1Electron Microscopic ExaminationHippocampusThalamusDisease PathogenesisTransgenic Mouse StrainsDrug TrialsTherapeutic AgentsStem Cell TransplantationImmunodeficiency Mouse Strains
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Shen, Y., Plane, J. M., Deng, W. Mouse Models of Periventricular Leukomalacia. J. Vis. Exp. (39), e1951, doi:10.3791/1951 (2010).
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