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Enrichment of Host Cell Proteins in Monoclonal Antibody Drug Products
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Author Spotlight: Detecting Low-Abundant Host Cell Proteins in Drug Products Using Enrichment Beads and Limited Digestion
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Host Cell Protein Analysis using Enrichment Beads Coupled with Limited Digestion

Author Spotlight: Detecting Low-Abundant Host Cell Proteins in Drug Products Using Enrichment Beads and Limited Digestion

1,349 Views

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02:35 min

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January 19, 2024

DOI:

10.3791/65544-v

DOI:
10.3791/65544-v

•

02:35 min
January 19, 2024

•

5 Views
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1Analytical Chemistry,Regeneron Pharmaceuticals Inc.

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Host Cell ProteinHCP AnalysisProteome Enrichment BeadsLimited DigestionDynamic RangeProteoMiner TechnologyNano LC-MS/MSMonoclonal AntibodyTherapeutic ProteinsImpuritiesRisk Assessment

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Zhang, S., Xiao, H., Li, N. Host Cell Protein Analysis using Enrichment Beads Coupled with Limited Digestion. J. Vis. Exp. (203), e65544, doi:10.3791/65544 (2024).

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