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病毒合并感染后 肺炎链球菌 从定植者转变为病原体的小鼠模型概括了年龄加重的疾病
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September 28, 2022
DOI:
1Department of Microbiology and Immunology,University at Buffalo School of Medicine, 2Department of Molecular Biology and Microbiology,Tufts University School of Medicine, 3Graduate Program in Immunology,Tufts Graduate School of Biomedical Sciences, 4Department of Translational Medicine,Lund University, 5Stuart B. Levy Center for the Integrated Management of Antimicrobial Resistance,Tufts University
Summary
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本文描述了一种新的小鼠模型，用于肺炎球菌在病毒感染期间从无症状定植者转变为致病病原体。该模型可以很容易地适应研究疾病进展不同阶段和各种宿主之间的多种微生物和宿主 - 病原体相互作用。
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Cite this Article
Lenhard, A., Joma, B. H., Siwapornchai, N., Hakansson, A. P., Leong, J. M., Bou Ghanem, E. N. A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness. J. Vis. Exp. (187), e64419, doi:10.3791/64419 (2022).
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