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低强度冲击波模型用于啮齿动物闭头轻度创伤性脑损伤的临床前评估
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06:09 min
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November 06, 2020
DOI:
1Geriatrics Research Education and Clinical Center,Veterans Affairs, 2Division of Gerontology and Geriatric Medicine,University of Washington, 3Department of Neurosurgery,University of Florida, 4Department of Neurosurgery,West Virginia University, 5Division of Pharmaceutical Sciences,University of Cincinnati, 6Central Illinois Neuro Health Sciences, Bloomington, IL, 7Neuro-research, Dallas, TX
Summary
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我们在这里提出了啮齿动物冲击波模型的方案，以研究轻度至中度创伤性脑损伤的神经生物学和病理生理学影响。我们建立了一个气体驱动的台式设置，配备了压力传感器，允许可靠和可重复地产生爆炸引起的轻度至中度创伤性脑损伤。
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Logsdon, A. F., Lucke-Wold, B. P., Turner, R. C., Collins, S. M., Reeder, E. L., Huber, J. D., Rosen, C. L., Robson, M. J., Plattner, F. Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents. J. Vis. Exp. (165), e61244, doi:10.3791/61244 (2020).
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