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遗传性痉挛性截瘫中人类诱导多能干细胞衍生神经元的线粒体迁移与形态分析
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Analyzing Mitochondrial Transport and Morphology in Human Induced Pluripotent Stem Cell-Derived Neurons in Hereditary Spastic Paraplegia
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遗传性痉挛性截瘫中人类诱导多能干细胞衍生神经元的线粒体迁移与形态分析

7,537 Views

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07:32 min

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February 09, 2020

DOI:

10.3791/60548-v

DOI:
10.3791/60548-v

•

07:32 min
February 09, 2020

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7 Views
, , , ,
1Department of Biomedical Sciences,University of Illinois College of Medicine Rockford, 2Department of Bioengineering,University of Illinois at Chicago, 3MD Program,University of Illinois College of Medicine Rockford

Summary

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受损的线粒体迁移和形态学涉及各种神经退行性疾病。提出的协议使用诱导多能干细胞衍生前脑神经元来评估线粒体迁移和遗传性痉挛性截瘫的形态。该协议允许沿斧子对线粒体贩运进行表征，并分析其形态，这将有助于神经退行性疾病的研究。

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Cite this Article

Mou, Y., Mukte, S., Chai, E., Dein, J., Li, X. Analyzing Mitochondrial Transport and Morphology in Human Induced Pluripotent Stem Cell-Derived Neurons in Hereditary Spastic Paraplegia. J. Vis. Exp. (156), e60548, doi:10.3791/60548 (2020).

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