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皿に血液脳腫瘍-障壁を使用して生体ペイロード配信で予測

JoVE 신문
암 연구학

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JoVE 신문 암 연구학

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish

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皿に血液脳腫瘍-障壁を使用して生体ペイロード配信で予測

8,792 Views

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13:34 min

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April 16, 2019

DOI:

10.3791/59384-v

DOI:

10.3791/59384-v

•

13:34 min

April 16, 2019

•

3 Views

Vadim Le Joncour¹, Sinem Karaman^1,2, Pirjo Maarit Laakkonen^1,3

¹Research Programs Unit, Translational Cancer Medicine Research Program,University of Helsinki, ²Wihuri Research Institute, Biomedicum Helsinki,University of Helsinki, ³Laboratory Animal Center, Helsinki Institute of Life Science (HiLIFE),University of Helsinki

Summary

中枢神経系腫瘍にターゲティングは大きな課題です。ここで我々はマウスやヒトの細胞を用いた血液脳腫瘍関門の in vitro における模倣を生産し、中枢神経系腫瘍生体内ターゲットの予測可能性の重要性を議論するためのプロトコルについて説明します。

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