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JoVE Journal Cancer Research
Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
 

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Article DOI: 10.3791/56386-v • 09:57 min • March 5th, 2018
March 5th, 2018 •
*1,2, *3, 1, 1, 3, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2,4, 1, 3, 1
1Department of Hematology, VU University Medical Center, 2Pediatric Oncology/Hematology, VU University Medical Center, 3Janssen Research & Development, LLC, 4Princess Máxima Center for Pediatric Oncology
* These authors contributed equally

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요약
Automatic Translation

Detection of minimal or measurable residual disease (MRD) is an important prognostic biomarker for refining risk assessment and predicting relapse in acute myeloid leukemia (AML). These comprehensive guidelines and recommendations with best practices for consistent and accurate identification and detection of MRD, may aid in making effective AML treatment decisions.

Tags

Bone Marrow Measurable Residual Disease Leukemic Stem Cells Acute Myeloid Leukemia Protocol Sample Processing Accurate Testing Quantification High-quality Results Clinical Decision-making Hematologist Technician Diagnostic Hematology Laboratory MRD Team Lateral Decubitus Position Iliac Spine Local Anesthetic 15-gauge Needle
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