Journal
/
생화학
/
Эффективный метод синтеза Пептоиды с мономерами смешанного типа Лизин / аргинин-типа и оценки их Анти-leishmanial деятельности
JoVE 신문
생화학
This content is Free Access.
JoVE 신문 생화학
An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Please note that all translations are automatically generated. Click here for the English version.

Эффективный метод синтеза Пептоиды с мономерами смешанного типа Лизин / аргинин-типа и оценки их Анти-leishmanial деятельности

11,664 Views

•

12:02 min

•

November 02, 2016

DOI:

10.3791/54750-v

DOI:
10.3791/54750-v

•

12:02 min
November 02, 2016

•

2 Views
, ,
1Department of Chemistry,Durham University, 2School of Medicine, Pharmacy and Health,Durham University

Summary

Automatically generated

A protocol to synthesize peptoids with mixed cationic functionality in the same sequence is presented (lysine- and arginine-type monomers). Subsequent testing of these compounds against Leishmania mexicana, the protozoan parasites that cause cutaneous leishmaniasis, is also described.

Explore More Videos

PeptoidsLysineArginineAnti-leishmanial ActivityCutaneous LeishmaniasisLeishmania MexicanaSubmonomer SynthesisFmoc-protected ResinPiperidineBromoacetic AcidDICAmine Solution

Read Article

Cite this Article

Bolt, H. L., Denny, P. W., Cobb, S. L. An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity. J. Vis. Exp. (117), e54750, doi:10.3791/54750 (2016).

Download .ris file

Copy

Share Video

.

Copy