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Een efficiënte methode voor de synthese van peptoïden met Gemengde lysine-type / Arginine-type monomeren en evaluatie van hun anti-leishmania Activity
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JoVE 신문 생화학
An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
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Een efficiënte methode voor de synthese van peptoïden met Gemengde lysine-type / Arginine-type monomeren en evaluatie van hun anti-leishmania Activity

11,645 Views

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12:02 min

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November 02, 2016

DOI:

10.3791/54750-v

DOI:
10.3791/54750-v

•

12:02 min
November 02, 2016

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2 Views
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1Department of Chemistry,Durham University, 2School of Medicine, Pharmacy and Health,Durham University

Summary

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A protocol to synthesize peptoids with mixed cationic functionality in the same sequence is presented (lysine- and arginine-type monomers). Subsequent testing of these compounds against Leishmania mexicana, the protozoan parasites that cause cutaneous leishmaniasis, is also described.

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PeptoidsLysineArginineAnti-leishmanial ActivityCutaneous LeishmaniasisLeishmania MexicanaSubmonomer SynthesisFmoc-protected ResinPiperidineBromoacetic AcidDICAmine Solution

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Cite this Article

Bolt, H. L., Denny, P. W., Cobb, S. L. An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity. J. Vis. Exp. (117), e54750, doi:10.3791/54750 (2016).

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