Использование функциональной геномики скрининг для выявления потенциально новых целей наркотиком в сфероида культур раковых клеток

Identifying novel drug targets that transition from pre-clinical testing to human trials is a scientific priority. To that end, here we describe a functional genomics approach for examining the impact of gene depletion on cancer cell line spheroids, which more appropriately model human cancers in vivo.