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A Step by Step Protocol for Subretinal Surgery in Rabbits
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September 13, 2016
DOI:
1Department of Ophthalmology,University of Bonn, 2Department of Ophthalmology,National University of Singapore, 3Geuder AG, 4Department of Ophthalmology,University of Münster, 5Section on Epithelial and Retinal Physiology and Disease,National Eye Institute/National Institutes of Health, 6Surgical Retina Department,Singapore National Eye Centre
Summary
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Retinal pigment epithelium (RPE) replacement strategies and gene-based therapy are considered for several retinal degenerative conditions. For clinical translation, large eye animal models are required to study surgical techniques applicable in patients. Here we present a rabbit model for subretinal surgery geared towards RPE transplantation, which is versatile and cost-efficient.
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Al-Nawaiseh, S., Thieltges, F., Liu, Z., Strack, C., Brinken, R., Braun, N., Wolschendorf, M., Maminishkis, A., Eter, N., Stanzel, B. V. A Step by Step Protocol for Subretinal Surgery in Rabbits. J. Vis. Exp. (115), e53927, doi:10.3791/53927 (2016).
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