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심근 구조, 기능의 생체 양적 평가에서 관류 및 생존 능력은 심장 마이크로 컴퓨터 단층 촬영을 사용하여
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생체공학
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JoVE 신문 생체공학
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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심근 구조, 기능의 생체 양적 평가에서 관류 및 생존 능력은 심장 마이크로 컴퓨터 단층 촬영을 사용하여

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08:13 min

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February 16, 2016

DOI:

10.3791/53603-v

DOI:
10.3791/53603-v

•

08:13 min
February 16, 2016

•

11 Views
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1Department of Genetics,Erasmus MC, Rotterdam, 2Department of Experimental Cardiology,Erasmus MC, Rotterdam, 3PerkinElmer, Inc., 4Department of Vascular Surgery,Erasmus MC, Rotterdam, 5Department of Radiation Oncology,Erasmus MC, Rotterdam

Summary

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This method outlines the use of Quantum Micro-Computed Tomography (MicroCT) to assess cardiac morphology, function, perfusion, metabolism and viability with iodinated contrast agent in mice with experimentally-induced myocardial ischemia. The technique can be applied for non-destructive high-throughput longitudinal in vivo imaging of various animal models of human heart disease.

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Cardiac Micro-computed TomographyMyocardial StructureMyocardial FunctionMyocardial PerfusionMyocardial ViabilityCardiac IschemiaCardiac PathophysiologyCardiac Disease DevelopmentCardiac ParametersNon-invasive EvaluationPreclinical ToolMouse ModelLeft Coronary Artery LigationInfarct InductionMicroCT Imaging

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van Deel, E., Ridwan, Y., van Vliet, J. N., Belenkov, S., Essers, J. In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography. J. Vis. Exp. (108), e53603, doi:10.3791/53603 (2016).

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