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In Vivo quantitativa valutazione della struttura del miocardio, la funzione, la perfusione e sostenibilità Utilizzando cardiaca micro-tomografia computerizzata
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February 16, 2016
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This method outlines the use of Quantum Micro-Computed Tomography (MicroCT) to assess cardiac morphology, function, perfusion, metabolism and viability with iodinated contrast agent in mice with experimentally-induced myocardial ischemia. The technique can be applied for non-destructive high-throughput longitudinal in vivo imaging of various animal models of human heart disease.
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Cardiac Micro-computed TomographyMyocardial StructureMyocardial FunctionMyocardial PerfusionMyocardial ViabilityCardiac IschemiaCardiac PathophysiologyCardiac Disease DevelopmentCardiac ParametersNon-invasive EvaluationPreclinical ToolMouse ModelLeft Coronary Artery LigationInfarct InductionMicroCT Imaging
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van Deel, E., Ridwan, Y., van Vliet, J. N., Belenkov, S., Essers, J. In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography. J. Vis. Exp. (108), e53603, doi:10.3791/53603 (2016).
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