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げっ歯類での抑うつ症状を扇動、行動の変化と負の健康アウトカムのための予測不可能な慢性的な軽度のストレスプロトコル
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An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
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げっ歯類での抑うつ症状を扇動、行動の変化と負の健康アウトカムのための予測不可能な慢性的な軽度のストレスプロトコル

21,929 Views

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06:55 min

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December 02, 2015

DOI:

10.3791/53109-v

DOI:
10.3791/53109-v

•

06:55 min
December 02, 2015

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15 Views
, , ,
1Department of Physiology and Pharmacology,West Virginia University Health Sciences Center, 2Division of Vascular and Endovascular Surgery, Center for Cardiovascular and Respiratory Sciences,West Virginia University Health Sciences Center

Summary

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The unpredictable chronic mild stress (UCMS) protocol is a validated method for studying behavioral and physiological changes associated with chronic stress and depressive symptoms. Eight weeks of imposition of the UCMS protocol induces behavioral changes and poor health outcomes in rodents of either gender.

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Unpredictable Chronic Mild StressUCMSRodent ModelDepressionAnhedoniaGrooming BehaviorLearned HelplessnessHypercortisolemiaHypertensionSSRIBehavioral ChangesNegative Health OutcomesCardiovascular System

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Cite this Article

Frisbee, J. C., Brooks, S. D., Stanley, S. C., d'Audiffret, A. C. An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents. J. Vis. Exp. (106), e53109, doi:10.3791/53109 (2015).

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