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腸間膜リンパダクトカニューレを挿入ラットモデル：腸のリンパ医薬品輸送の評価への応用
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March 06, 2015
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Here we describe a technique to cannulate the mesenteric lymph duct in rats which enables quantification of lipid and drug transport via the lymphatic system following intestinal delivery. The technique can be adapted to assess mesenteric lymph concentrations and/or transport of fluid, immune cells, peptides, proteins and lipophilic molecules.
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Trevaskis, N. L., Hu, L., Caliph, S. M., Han, S., Porter, C. J. The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport. J. Vis. Exp. (97), e52389, doi:10.3791/52389 (2015).
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