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Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms
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Neuroscience
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JoVE Journal Neuroscience
Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

English

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780 Views

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08:28 min

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March 03, 2023

DOI:

10.3791/65042-v

DOI:
10.3791/65042-v

•

08:28 min
March 03, 2023

•

9 Views
, , , ,
1Department of Biomedical Engineering,Worcester Polytechnic Institute, 2Graduate School of Biomedical Sciences,UMass Chan Medical School, 3Department of Biology and Biotechnology,Worcester Polytechnic Institute

Summary

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We present a method for the flexible chemical and multimodal stimulation and recording of simultaneous neural activity from many Caenorhabditis elegans worms. This method uses microfluidics, open-source hardware and software, and supervised automated data analysis to enable the measurement of neuronal phenomena such as adaptation, temporal inhibition, and stimulus crosstalk.

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Automated StimulationMultimodal StimulationSimultaneous Neuronal RecordingMultiple Small OrganismsNeural ResponsesBrain ActivityRepeatabilityNeuronal VariabilityAdaptationSensory IntegrationMicrofluidic DeviceWorm LoadingNeural Phenomena

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Cite this Article

White, H., Kamara, V., Gorski, V., Busby, M., Albrecht, D. R. Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms. J. Vis. Exp. (193), e65042, doi:10.3791/65042 (2023).

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