Journal
/
Neurowissenschaften
/
Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms
JoVE Journal
Neurowissenschaften
Zum Anzeigen dieser Inhalte ist ein JoVE-Abonnement erforderlich.  Melden Sie sich an oder starten Sie Ihre kostenlose Testversion.
JoVE Journal Neurowissenschaften
Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

780 Views

•

08:28 min

•

March 03, 2023

DOI:

10.3791/65042-v

DOI:
10.3791/65042-v

•

08:28 min
March 03, 2023

•

9 Views
, , , ,
1Department of Biomedical Engineering,Worcester Polytechnic Institute, 2Graduate School of Biomedical Sciences,UMass Chan Medical School, 3Department of Biology and Biotechnology,Worcester Polytechnic Institute

Summary

Automatically generated

We present a method for the flexible chemical and multimodal stimulation and recording of simultaneous neural activity from many Caenorhabditis elegans worms. This method uses microfluidics, open-source hardware and software, and supervised automated data analysis to enable the measurement of neuronal phenomena such as adaptation, temporal inhibition, and stimulus crosstalk.

Explore More Videos

Automated StimulationMultimodal StimulationSimultaneous Neuronal RecordingMultiple Small OrganismsNeural ResponsesBrain ActivityRepeatabilityNeuronal VariabilityAdaptationSensory IntegrationMicrofluidic DeviceWorm LoadingNeural Phenomena

Read Article

Cite this Article

White, H., Kamara, V., Gorski, V., Busby, M., Albrecht, D. R. Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms. J. Vis. Exp. (193), e65042, doi:10.3791/65042 (2023).

Download .ris file

Copy

Share Video

.

Copy