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Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol
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Chemistry
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JoVE Journal Chemistry
Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol

Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol

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2,937 Views

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08:33 min

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September 21, 2021

DOI:

10.3791/63025-v

DOI:
10.3791/63025-v

•

08:33 min
September 21, 2021

•

2 Views
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1Diagnostic & Research PET/MRI Center,Nemours/Alfred I. duPont Hospital for Children, 2Department of Radiology,Nemours/Alfred I. duPont Hospital for Children, 3Department of Neurology,Nemours/Alfred I. duPont Hospital for Children, 4Department of Biomedical Research,Nemours/Alfred I. duPont Hospital for Children

Summary

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Here, we describe the radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-tryptophan, a positron emission tomography imaging agent for studying tryptophan metabolism, using a one-pot, two-step strategy in a radiochemistry synthesis system with good radiochemical yields, high enantiomeric excess, and high reliability.

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Yue, X., Nikam, R. M., Kecskemethy, H. H., Kandula, V. V. R., Falchek, S. J., Averill, L. W., Langhans, S. A. Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol. J. Vis. Exp. (175), e63025, doi:10.3791/63025 (2021).

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