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A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties
JoVE Journal
Cancer Research
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JoVE Journal Cancer Research
A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

English

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5,878 Views

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08:40 min

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August 07, 2020

DOI:

10.3791/61606-v

DOI:
10.3791/61606-v

•

08:40 min
August 07, 2020

•

13 Views
, , , , ,
1Department of Medical Cell Biology,Uppsala University, 2Polymer Chemistry, Department of Chemistry-Ångström Laboratory,Uppsala University

Summary

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This protocol presents a 3D biomimetic model with accompanying fibrotic stromal compartment. Prepared with physiologically relevant hydrogels in ratios mimicking the bio-physical properties of the stromal extracellular matrix, an active mediator of cellular interactions, tumor growth and metastasis.

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Cite this Article

Calitz, C., Pavlović, N., Rosenquist, J., Zagami, C., Samanta, A., Heindryckx, F. A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties. J. Vis. Exp. (162), e61606, doi:10.3791/61606 (2020).

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