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A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
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Immunology and Infection
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JoVE Journal Immunology and Infection
A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

English

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17,263 Views

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09:52 min

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August 08, 2014

DOI:

10.3791/51556-v

DOI:
10.3791/51556-v

•

09:52 min
August 08, 2014

•

6 Views
, , , , , , ,
1Department of Medicine, Section of Infectious Disease,Boston University School of Medicine, 2Department of Biophysics,Boston University School of Medicine

Summary

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Animal models have proven to be invaluable tools in defining host and pathogen specific mechanisms that contribute to the development of chronic inflammation. Here we describe a mouse model of oral infection with the human pathogen Porphyromonas gingivalis and detail methodologies to assess the progression of inflammation at local and systemic sites.

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Cite this Article

Papadopoulos, G., Kramer, C. D., Slocum, C. S., Weinberg, E. O., Hua, N., Gudino, C. V., Hamilton, J. A., Genco, C. A. A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites. J. Vis. Exp. (90), e51556, doi:10.3791/51556 (2014).

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