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Immunology and Infection

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JoVE Journal Immunology and Infection
A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
 

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Article DOI: 10.3791/51556-v • 09:52 min • August 8th, 2014
August 8th, 2014 •
*1, *1, 1, 1, 2, 1, 1, 1
1Department of Medicine, Section of Infectious Disease, Boston University School of Medicine, 2Department of Biophysics, Boston University School of Medicine
* These authors contributed equally

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résumé
Automatic Translation

Animal models have proven to be invaluable tools in defining host and pathogen specific mechanisms that contribute to the development of chronic inflammation. Here we describe a mouse model of oral infection with the human pathogen Porphyromonas gingivalis and detail methodologies to assess the progression of inflammation at local and systemic sites.

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Keywords: Mouse Model Chronic Inflammation Pathogen-induced Porphyromonas Gingivalis Periodontal Disease Atherosclerosis Inflammatory Response Alveolar Bone Vascular Endothelium Inflammatory Mediators Transgenic Mice Bacterial Mutants Therapeutic Strategies
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