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September 02, 2010
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We seek to define the neural immune signaling responsible for cold-preconditioning as means to identify novel targets for therapeutics development to protect brain before injury onset. We present strategies for such work that require biological systems, experimental manipulations plus technical capacities that are highly reproducible and sensitive.
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NeuroprotectionCold-preconditioningNeurological InjuryAnesthesiaSurgical ProceduresPreconditioning TreatmentsNeural Immune SignalingTherapeutics DevelopmentPro-inflammatory Mediator SignalingPhysiological Conditioning HormesisIrritative StimuliAdaptationImmune SignalingHippocampal Slice CulturesIn Vitro ModelMulti-synaptic Neural NetworksMacrogliaMicroglia
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Mitchell, H. M., White, D. M., Kraig, R. P. Strategies for Study of Neuroprotection from Cold-preconditioning. J. Vis. Exp. (43), e2192, doi:10.3791/2192 (2010).
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