Here, we present a protocol for the scaled-up synthesis of the intermediate tert-butyl (5-toluenesulfonyl-5h-pyrrole [2,3-b] pyrazine-2-yl) carbamate (ACT051-3) of Upatinib.
Zhang, L., Xue, W., Li, Q., Liu, H., Xie, D. Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3. J. Vis. Exp. (194), e64514, doi:10.3791/64514 (2023).