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Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
JoVE 杂志
化学
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JoVE 杂志 化学
Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3

DOI:
10.3791/64514-v

•

08:36 min

•

April 07, 2023

•

, , , ,
1Aneo Chem-Tech Co., Ltd

Chapters

  • 00:04Introduction
  • 00:25Pilot Scale Synthesis of Compounds ACT051‐2 and ACT051‐3
  • 03:12Pilot Scale‐Up Synthesis of Compounds ACT051‐2 and ACT051‐3
  • 05:59Results: Synthesis Route and the Effect of Different Conditions on the Synthesis of ACT051‐3
  • 08:09Conclusion

Summary

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Here, we present a protocol for the scaled-up synthesis of the intermediate tert-butyl (5-toluenesulfonyl-5h-pyrrole [2,3-b] pyrazine-2-yl) carbamate (ACT051-3) of Upatinib.

Tags

Scaled-up SynthesisUpatinib IntermediateACT051-3ACT051-2DMFDIPEATsClPalladium AcetateXantphosColumn ChromatographyPilot Scale-up

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