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Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis
章
- 00:05Introduction
- 01:08Pre-Operative Care
- 02:21Destabilization of the Medial Meniscus Procedure Followed by Cartilage Scratch
- 04:16Post-Operative Care and Evaluation of Osteoarthritic Disease
- 05:29Results: Destabilization of the Medial Meniscus and Cartilage Scratch Model to Study Post-Traumatic Osteoarthritis
- 06:24Conclusion
The present protocol describes the controlled microblade scratches on the surface of the articular cartilage after destabilizing the mouse knee by cutting the medial miniscotibial ligament. This animal model presents an accelerated form of osteoarthritis (OA) suitable for studying osteophyte formation, osteosclerosis, and early-stage pain.
