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Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis
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Medicina
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JoVE Revista Medicina
Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis

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07:06 min

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July 06, 2022

DOI:

10.3791/64159-v

DOI:
10.3791/64159-v

•

07:06 min
July 06, 2022

•

29 Views
, , , ,
1Institute of Biomedical and Environmental Health Research,University of the West of Scotland, 2Institute of Infection, Immunity and Inflammation,University of Glasgow

Summary

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The present protocol describes the controlled microblade scratches on the surface of the articular cartilage after destabilizing the mouse knee by cutting the medial miniscotibial ligament. This animal model presents an accelerated form of osteoarthritis (OA) suitable for studying osteophyte formation, osteosclerosis, and early-stage pain.

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Cite this Article

Dunning, L., McCulloch, K., Lockhart, J. C., Goodyear, C. S., Huesa, C. Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis. J. Vis. Exp. (185), e64159, doi:10.3791/64159 (2022).

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