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Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions
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JoVE Journal 神経科学
Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions

2,573 Views

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08:40 min

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June 23, 2022

DOI:

10.3791/64050-v

DOI:
10.3791/64050-v

•

08:40 min
June 23, 2022

•

6 Views
,
1Living Systems Institute, Department of Biosciences,University of Exeter

タグ

Alpha-synucleinHydrogen/deuterium ExchangeMass SpectrometryIntrinsically Disordered ProteinsPeptide MappingSample PreparationAutosamplerHDX RoboticsQuench BufferPeptide Coverage MapFast HDX Prototype InstrumentHDX Data Analysis Software

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Seetaloo, N., Phillips, J. J. Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions. J. Vis. Exp. (184), e64050, doi:10.3791/64050 (2022).

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