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A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease
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A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease

DOI:
10.3791/62033-v

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07:17 min

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January 29, 2021

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, , , , , , , , , ,
1Department of Neuro-Oncology,H. Lee Moffitt Cancer Center & Research Institute, 2Department of Tumor Biology,H. Lee Moffitt Cancer Center & Research Institute, 3Department of Comparative Medicine,University of South Florida, 4Department of Breast Oncology,H. Lee Moffitt Cancer Center & Research Institute, 5Department of Cancer Physiology,H. Lee Moffitt Cancer Center & Research Institute, 6Department of Drug Discovery,H. Lee Moffitt Cancer Center & Research Institute, 7Department of Medical Oncology,Roswell Park Comprehensive Cancer Center

章

  • 00:04Introduction
  • 01:07Injection of CTCs into CSF to Generate a Mouse LMD Model
  • 03:37Murine Ommaya Assembly and Implantation
  • 05:20Results: Direct-Targeted Immunotherapy Using the Murine Ommaya Increases the Overall Survival of Breast Cancer-Associated Leptomeningeal Disease Mice
  • 06:37Conclusion

概要

自動翻訳

自動翻訳

Here, we describe a murine xenograft model that functionally resembles an Ommaya reservoir in patients. We developed the Murine Ommaya to study novel therapeutics for the universally fatal leptomeningeal disease.

タグ

Murine OmmayaXenograft ModelLeptomeningeal DiseaseDirect-targeted TherapyBrain MetastasesCerebrospinal FluidBlood-brain BarrierStereotactic SurgeryBuprenorphineCisterna MagnaHamilton SyringeDural Membrane

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