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A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease
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January 29, 2021
DOI:
1Department of Neuro-Oncology,H. Lee Moffitt Cancer Center & Research Institute, 2Department of Tumor Biology,H. Lee Moffitt Cancer Center & Research Institute, 3Department of Comparative Medicine,University of South Florida, 4Department of Breast Oncology,H. Lee Moffitt Cancer Center & Research Institute, 5Department of Cancer Physiology,H. Lee Moffitt Cancer Center & Research Institute, 6Department of Drug Discovery,H. Lee Moffitt Cancer Center & Research Institute, 7Department of Medical Oncology,Roswell Park Comprehensive Cancer Center
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Here, we describe a murine xenograft model that functionally resembles an Ommaya reservoir in patients. We developed the Murine Ommaya to study novel therapeutics for the universally fatal leptomeningeal disease.
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Law, V., Baldwin, M., Ramamoorthi, G., Kodumudi, K., Tran, N., Smalley, I., Duckett, D., Kalinski, P., Czerniecki, B., Smalley, K. S. M., Forsyth, P. A. A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease. J. Vis. Exp. (167), e62033, doi:10.3791/62033 (2021).
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