This article demonstrates an extradural approach to obliterate the guinea pig endolymphatic sac and injure the endolymphatic duct with a fine pick in order to induce experimental endolymphatic hydrops.
Valenzuela, C. V., Lee, C., Buchman, C. A., Lichtenhan, J. T. A Revised Surgical Approach to Induce Endolymphatic Hydrops in the Guinea Pig. J. Vis. Exp. (160), e60597, doi:10.3791/60597 (2020).