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Métodos para el descubrimiento de nuevos compuestos modular un Receptor del ácido Gamma - Aminobutírico tipo una neurotransmisión
JoVE Journal
神経科学
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JoVE Journal 神経科学
Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Métodos para el descubrimiento de nuevos compuestos modular un Receptor del ácido Gamma - Aminobutírico tipo una neurotransmisión

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07:16 min

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August 16, 2018

DOI:

10.3791/57842-v

DOI:
10.3791/57842-v

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07:16 min
August 16, 2018

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1Discovery Neuroscience, Pharma Research and Early Development,Roche Innovation Center Basel, 2HiQScreen Sàrl 6

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GABA-A ReceptorRadioligand Binding電気生理学Xenopus OocytesRodent Brain SlicesCompound ScreeningSubtype SelectivityEfficacyMicroinjectionVoltage ClampPopulation Spike RecordingHippocampus

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Knoflach, F., Hernandez, M., Bertrand, D. Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission. J. Vis. Exp. (138), e57842, doi:10.3791/57842 (2018).

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