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De Novo Generation of Somatic Stem Cells by YAP/TAZ
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May 07, 2018
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Availability of somatic SCs is crucial for regenerative medicine, disease modeling and to gain insight into SC properties. Here we present experimental strategies to reprogram, in vitro, differentiated adult cells into their corresponding expandable tissue-specific stem/progenitor cells by the transient expression of the single transcriptional co-activator YAP.
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Panciera, T., Azzolin, L., Di Biagio, D., Totaro, A., Cordenonsi, M., Piccolo, S. De Novo Generation of Somatic Stem Cells by YAP/TAZ. J. Vis. Exp. (135), e57462, doi:10.3791/57462 (2018).
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