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De Novo Generation of Somatic Stem Cells by YAP/TAZ
 

De Novo Generation of Somatic Stem Cells by YAP/TAZ

Article DOI: 10.3791/57462-v • 13:05 min • May 7th, 2018
May 7th, 2018 •
1, 1, 1, 1, 1, 1
1Department of Molecular Medicine, University of Padua School of Medicine

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Availability of somatic SCs is crucial for regenerative medicine, disease modeling and to gain insight into SC properties. Here we present experimental strategies to reprogram, in vitro, differentiated adult cells into their corresponding expandable tissue-specific stem/progenitor cells by the transient expression of the single transcriptional co-activator YAP.

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De Novo Generation Somatic Stem Cells YAP/TAZ Reprogramming Procedure Progenitor Cells Transcription Factor YAP Differentiated Cells Stem-like Cells Tissue-specific Stem Cells Regenerative Medicine Cell Plasticity Cancer Research Cell Tissue Development Mammary Glands Dissection HBSS+PS Solution Tissue Culture Hood
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