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Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain
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Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain

Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain

9,172 Views

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08:23 min

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May 12, 2018

DOI:

10.3791/57391-v

DOI:
10.3791/57391-v

•

08:23 min
May 12, 2018

•

2 Views
, , , , , , , , , ,
1Department of Anesthesiology,Ohio State University College of Medicine, 2Medical Student Research Program,Ohio State University College of Medicine, 3Department of Anesthesiology and Pain Medicine,Nationwide Children’s Hospital, 4神経科学科,University of Kentucky Medical Center

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This study explores the novel use of enzyme-based microelectrode array (MEA) technology to monitor in vivo neurotransmitter activity in piglets. The hypothesis was that glutamate dysregulation contributes to the mechanism of anesthetic neurotoxicity. Here, we present a protocol to adapt MEA technology to study the mechanism of anesthesia-induced neurotoxicity.

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Geyer, E. D., Shetty, P. A., Suozzi, C. J., Allen, D. Z., Benavidez, P. P., Liu, J., Hollis, C. N., Gerhardt, G. A., Quintero, J. E., Burmeister, J. J., Whitaker, E. E. Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain. J. Vis. Exp. (135), e57391, doi:10.3791/57391 (2018).

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