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利用18f-葡萄糖 PET/CT 成像和定量组织学测量肺癌小鼠模型葡萄糖代谢的动态变化
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06:51 min
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July 21, 2018
DOI:
1Division of Pulmonary and Critical Care Medicine,University of California Los Angeles David Geffen School of Medicine, 2University of North Carolina at Chapel Hill, 3Department of Molecular and Medical Pharmacology,University of California Los Angeles, 4Andor Technology, 5Division of Orthopaedic Surgery,University of California Los Angeles David Geffen School of Medicine
概要
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在本协议中, 我们描述如何利用 [18F]-2-氟 2-脱氧 d-葡萄糖正电子发射断层扫描和计算机断层扫描 (18MLN0128 PET/CT) 成像, 以测量肿瘤代谢反应的靶向治疗在Kras/Lkb1突变小鼠肺癌模型及高分辨率体外显影成像与定量组织学的结合。
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Momcilovic, M., Bailey, S. T., Lee, J. T., Zamilpa, C., Jones, A., Abdelhady, G., Mansfield, J., Francis, K. P., Shackelford, D. B. Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer. J. Vis. Exp. (137), e57167, doi:10.3791/57167 (2018).
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