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Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
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JoVE Journal 神経科学
Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

9,290 Views

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09:39 min

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February 13, 2018

DOI:

10.3791/56651-v

DOI:
10.3791/56651-v

•

09:39 min
February 13, 2018

•

6 Views
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1Department of Anatomy, School of Medicine, College of Medicine,Kaohsiung Medical University, 2Department of Medical Research,Kaohsiung Medical University Hospital, 3Department of Medical Research, Ultrastructural Laboratory,Kaohsiung Medical University Hospital

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This study establishes an experimental model of pure small fiber neuropathy with resiniferatoxin (RTX). A unique dose of RTX (50 µg/kg) is optimal for developing a small fiber neuropathy model that mimics patient characteristics and could help investigate the nociceptive molecular significance underlying neuropathic pain.

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Lee, Y., Lu, S., Hsieh, Y. Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1. J. Vis. Exp. (132), e56651, doi:10.3791/56651 (2018).

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