Rivista
/
Neuroscienze
/
Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
JoVE Journal
Neuroscienze
È necessario avere un abbonamento a JoVE per visualizzare questo.  Accedi o inizia la tua prova gratuita.
JoVE Journal Neuroscienze
Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

9,290 Views

•

09:39 min

•

February 13, 2018

DOI:

10.3791/56651-v

DOI:
10.3791/56651-v

•

09:39 min
February 13, 2018

•

6 Views
, ,
1Department of Anatomy, School of Medicine, College of Medicine,Kaohsiung Medical University, 2Department of Medical Research,Kaohsiung Medical University Hospital, 3Department of Medical Research, Ultrastructural Laboratory,Kaohsiung Medical University Hospital

Summary

Automatically generated

This study establishes an experimental model of pure small fiber neuropathy with resiniferatoxin (RTX). A unique dose of RTX (50 µg/kg) is optimal for developing a small fiber neuropathy model that mimics patient characteristics and could help investigate the nociceptive molecular significance underlying neuropathic pain.

Explore More Videos

Mouse ModelSmall Fiber NeuropathyTransient Receptor Potential Vanilloid Type 1ResiniferatoxinRTXHot Plate TestVon Frey Hair FilamentsSensory NeuropathyNeurotoxin Delivery

Read Article

Cite this Article

Lee, Y., Lu, S., Hsieh, Y. Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1. J. Vis. Exp. (132), e56651, doi:10.3791/56651 (2018).

Download .ris file

Copy

Share Video

.

Copy