How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases

Mercedes Rodriguez-Teja; Claudia Breit; Mitchell Clarke; Kamil Talar; Kai Wang; Mohammad A. Mohammad; Sage Pickwell; Guillermina Etchandy; Graeme J. Stasiuk; Justin Sturge

doi:10.3791/54230

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How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases

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How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases

9,352 Views

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13:18 min

•

September 20, 2016

DOI:

10.3791/54230-v

DOI:

10.3791/54230-v

•

13:18 min

September 20, 2016

•

2 Views

Mercedes Rodriguez-Teja¹, Claudia Breit², Mitchell Clarke³, Kamil Talar³, Kai Wang³, Mohammad A. Mohammad³, Sage Pickwell³, Guillermina Etchandy¹, Graeme J. Stasiuk³, Justin Sturge³

¹Departamento de Genética, Facultad de Medicina,Universidad de la República (UDELAR), ²Department of Mechanistic Cell Biology,Max Planck Institute of Molecular Physiology, ³School of Biological, Biomedical & Environmental Sciences,University of Hull

概要

Here we explain a protocol for modelling the biophysical microenvironment where crosslinking and increased stiffness of the basement membrane (BM) induced by advanced glycation endproducts (AGEs) has pathological relevance.

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How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases

概要

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