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Nörodejeneratif Hastalıkların bir Drosophila Modelinde Tırmanma Kusur Kantitatif Analiz
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JoVE Journal 神経科学
Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders
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Nörodejeneratif Hastalıkların bir Drosophila Modelinde Tırmanma Kusur Kantitatif Analiz

18,011 Views

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06:30 min

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June 13, 2015

DOI:

10.3791/52741-v

DOI:
10.3791/52741-v

•

06:30 min
June 13, 2015

•

26 Views
, , , , , , , ,
1小児科,University of Alberta, 2Montreal Neurological Institute and Hospital,McGill University

概要

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We present an optimized inexpensive and reliable negative geotaxis assay in Drosophila melanogaster as a model for neurodegenerative disorders. Being more sensitive to mild locomotor defects, this assay will help screen for potential genetic interactions and drug targets.

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Climbing DefectsDrosophila ModelNeurodegenerative DisordersLocomotive DefectsWhole Exome SequencingLocomotive FunctioningNegative Geotaxis AssayMobility DysfunctionsDrosophila MutantsLocomotion Defects

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Madabattula, S. T., Strautman, J. C., Bysice, A. M., O’Sullivan, J. A., Androschuk, A., Rosenfelt, C., Doucet, K., Rouleau, G., Bolduc, F. Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders. J. Vis. Exp. (100), e52741, doi:10.3791/52741 (2015).

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